BMRB Entry 17297
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PDB ID:
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR17297
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Title: NMR Solution structure of GLP-2 in DHPC micelles PubMed: 21167157
Deposition date: 2010-11-12 Original release date: 2011-03-30
Authors: Venneti, Kalyana; Hewage, Chandralal
Citation: Venneti, Kalyana; Hewage, Chandralal. "Conformational and molecular interaction studies of glucagon-like peptide-2 with its N-terminal extracellular receptor domain." FEBS Lett. 585, 346-352 (2011).
Assembly members:
GLP-2, polymer, 33 residues, 3769.167 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: chemical synthesis
Entity Sequences (FASTA):
GLP-2: HADGSFSDEMNTILDNLAAR
DFINWLIQTKITD
- assigned_chemical_shifts
| Data type | Count |
| 1H chemical shifts | 215 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | GLP-2 | 1 |
Entities:
Entity 1, GLP-2 33 residues - 3769.167 Da.
| 1 | HIS | ALA | ASP | GLY | SER | PHE | SER | ASP | GLU | MET | ||||
| 2 | ASN | THR | ILE | LEU | ASP | ASN | LEU | ALA | ALA | ARG | ||||
| 3 | ASP | PHE | ILE | ASN | TRP | LEU | ILE | GLN | THR | LYS | ||||
| 4 | ILE | THR | ASP |
Samples:
sample_1: DHPC 350 mM
sample_conditions_1: pH: 3.9; temperature: 273 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| 2D 1H-1H TOCSY | sample_1 | isotropic | sample_conditions_1 |
| 2D 1H-1H NOESY | sample_1 | isotropic | sample_conditions_1 |
Software:
CYANA v2.0, Guntert, Mumenthaler and Wuthrich - structure solution
NMR spectrometers:
- Bruker DRX 500 MHz
Related Database Links:
| BMRB | 17296 |
| PDB | |
| GB | EAX11358 |
| REF | XP_002749449 XP_002812569 XP_003266221 XP_003309324 XP_003820986 |