BMRB Entry 4650
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR4650
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Title: Sheep prion protein synthetic peptide spanning helix 1 and b strand 2 (residues 142 to 166) shows b hairpin structure in solution PubMed: 11577109
Deposition date: 2000-10-05 Original release date: 2002-06-26
Authors: Kozin, S.; Bertho, G.; Mazur, A.; Rabesona, H.; Girault, J.-P.; Haertle, T.; Takahashi, M.; Debey, P.; Hui Bon Hoa, G.
Citation: Kozin, S.; Bertho, G.; Mazur, A.; Rabesona, H.; Girault, J.-P.; Haertle, T.; Takahashi, M.; Debey, P.; Hui Bon Hoa, G.. "Structural Duality of a Peptide from Sheep Prion Protein may be One of the Causes of Prion Conversion" J. Biol. Chem. 276, 46364-46370 (2001).
Assembly members:
Major Prion Protein, polymer, 26 residues, Formula weight is not available
Natural source: Common Name: Sheep Taxonomy ID: 9940 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Ovis aries
Experimental source: Production method: chemical synthesis
Entity Sequences (FASTA):
Major Prion Protein: GNDYEDRYYRENMYRYPNQV
YYRPVC
- assigned_chemical_shifts
- coupling_constants
| Data type | Count |
| 1H chemical shifts | 201 |
| coupling constants | 19 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | SHEEP PRION PEPTIDE | 1 |
Entities:
Entity 1, SHEEP PRION PEPTIDE 26 residues - Formula weight is not available
| 1 | GLY | ASN | ASP | TYR | GLU | ASP | ARG | TYR | TYR | ARG | ||||
| 2 | GLU | ASN | MET | TYR | ARG | TYR | PRO | ASN | GLN | VAL | ||||
| 3 | TYR | TYR | ARG | PRO | VAL | CYS |
Samples:
sample_1: Major Prion Protein 4.5 mM; sodium phosphate 10 mM; H2O 90%; D2O 10%
sample_cond_1: ionic strength: 15 mM; pH: 6.5; pressure: 1 atm; temperature: 278 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| 1D, 2D DQF-COSY | sample_1 | not available | sample_cond_1 |
| 2D NOESY | sample_1 | not available | sample_cond_1 |
| 2D ROESY | sample_1 | not available | sample_cond_1 |
| 2D TOCSY | sample_1 | not available | sample_cond_1 |
| PFG HSQC | sample_1 | not available | sample_cond_1 |
| PFG HMBC | sample_1 | not available | sample_cond_1 |
| 2D 1H-13C HSQC | sample_1 | not available | sample_cond_1 |
| 2D 1H-13C HMBC | sample_1 | not available | sample_cond_1 |
Software:
xwinnmr v2.1 - collection
NMR spectrometers:
- Bruker AMX 500 MHz
Related Database Links:
| BMRB | 15394 15399 16328 16616 25250 25251 |
| PDB | |
| DBJ | BAA07376 BAB69955 BAB69956 BAD51981 BAE91721 |
| EMBL | CAA04234 CAA04235 CAA04236 CAA04272 CAA04273 |
| GB | AAA68634 AAA68635 AAA68941 AAB03105 AAB50623 |
| PRF | 1921132A |
| REF | NP_001009481 NP_001040617 NP_001075490 NP_001124544 NP_001137270 |
| SP | O18754 P23907 P40245 P40246 P40247 |
| TPE | CAJ43808 CAL59564 |